侯敦仁
職稱 教授
姓名 侯敦仁
電子郵件 drhou@cc.ncu.edu.tw
聯絡電話 (03) 4227151 ext. 65981
專業領域 有機化學
研究專長 開發具鏡像選擇性之有機催化劑與具有生物活性之天然物
學歷
國家 學校名稱 系所 學位
臺灣 臺灣大學 化學系 學士
臺灣 臺灣大學 化學系 碩士
美國 德州大學 化學系 博士
經歷
服務機關名稱 單位 職務 期間
國立中央大學 化學學系 主任 2015.08 ~ 2018.07
國立中央大學 化學系 教授 2011.01 ~ 0000.01
國立中央大學 化學系 副教授 2006.01 ~ 2011.01
國立中央大學 化學系 助理教授 2003.01 ~ 2006.01
國立高雄大學 應化系 助理教授 2001.01 ~ 2003.01
美國德州大學 博士後研究 2000.01 ~ 2001.01
美國德州農工大學 博士後研究 1998.01 ~ 2000.01
榮譽
類別 年度 獎項名稱 頒獎單位
校內榮譽 2011 中央大學學術研究傑出獎
個人研究

研究興趣
我們的研究領域主要是新型有機反應的設計與開發,並應用到有機合成上。合成的標的物是天然物或是具有特殊性質的分子。目前研究的反應多是由有機金屬錯合物催化碳—碳鍵的生成,如耦合、歧化反應等。
目前研究的主題有︰
1. 利用合環歧化反應(ring closing metathesis)和交叉歧化反應(cross metathesis)合成天然物。
2. 利用掌性集團(chiral auxiliary)進行不對稱反應。
3. 人造輔媒(cofactor)的合成和應用。
期刊論文
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  1. Chi-Yun Liu, Venkatachalam Angamuthu, Wei-Chen Chen, and Duen-Ren Hou. "Synthesis of Methyl l-Kijanosides by Regio-and Stereoselective Ring Opening of 2-Oxazolidinone-Fused Aziridines. " Organic Letters, 2020, 22(6), 2246-2250.
  1. She-Hung Chan, Wohn-Jenn Leu, Sharada Prasanna Swain, Jui-Ling Hsu, Duen-Ren Hou, and Jih-Hwa Guh."Mechanistic Study of Triazole Based Aminodiol Derivatives in Leukemic Cells—Crosstalk between Mitochondrial Stress-Involved Apoptosis and Autophagy."International Journal of Molecular Sciences, 2020, 21(7), 2470.
  1. Le Thi Ngoc Chuc, Thi Anh Hong Nguyen and Duen-Ren Hou. "Acid–base-sensitive allylic oxidation of 2-allylbenzoic acids to form phthalides. "Organic & Biomolecular Chemistry, 2020 18(14), 2758-2768.
  1. Hsin-Ying Wu, Wei-Yi Wang, Chia-Chi FengChia-Chi Feng, Chia-Chi Feng, Duen-Ren Hou, "Asymmetric Synthesis of Nabscessin A from Inositol and d-Camphor. " The Journal of Organic Chemistry, 2020, 85(20), 13153-13159.
  1. Yi-Hua Sheng, Wohn-Jenn Leu, Ching-Nung Chen, Jui-Ling Hsu, Ying-Tung Liu, Lih-Ching Hsu, Duen-Ren Hou,Jih-Hwa Guh, "The (+)-Brevipolide H Displays Anticancer Activity against Human Castration-Resistant Prostate Cancer: The Role of Oxidative Stress and Akt/mTOR/p70S6K-Dependent Pathways in G1 Checkpoint Arrest and Apoptosis." Molecules, 2020, 25(12), 2929.
  1. Ya-Ching Chang, Yu-Ling Tseng, Wohn-Jenn Leu, Chi-Min Du, Yi-Huei Jiang, Lih-Ching Hsu, Jui-Ling Hsu, Duen-Ren Hou, Jih-Hwa Guh, "Discovery of novel agents on spindle assembly checkpoint to sensitize vinorelbine-induced mitotic cell death against human non-small cell lung cancers." International journal of molecular sciences, 2020, 21(16), 5608.
  1. YuChun Wu, Yi Jhong, HuiJie Lin, Sharada Prasanna Swain, HuiHsu Gavin Tsai, DuenRen Hou, "Organocatalyzed Enantioselective Michael Addition of 2Hydroxypyridines and α,βUnsaturated 1,4Dicarbonyl Compounds." Advanced Synthesis & Catalysis, 2019, 361(21), 4966-4982.
  1. Trimurtulu, Kotipalli and Duen-Ren Hou "Synthesis of 3-Bromoindenes from 4-Alkynyl Alcohols/Sulfonamides and Aldehydes via Prins Cyclization, Ring-Opening and Friedel-Crafts Reactions." Asian Journal of Organic Chemistry, 2019, 8(8), 1561-1571.
  1. Kotipalli, Trimurtulu, and Duen-Ren Hou "Synthesis of Indenes by a BF3· OEt2-Mediated, One-Pot Reaction of Aryl Homopropargyl Alcohols, Aldehydes, and Arenes." Organic letters, 2018, 20(16), 4787-4790.
  1. Agata Szymaszkiewicz, Marta Zielinska, Kun Li, Mani Ramanathan, Safiul Alam,  Duen-Ren Hou, Jakub Fichna, Martin Storr "Novel derivatives of 1, 2, 3-triazole,cannabinoid-1 receptor ligands modulate gastrointestinal motility in mice." Naunyn-Schmiedeberg's archives of pharmacology, 2018, 391(4), 435-444.
  1. Venkatachalam Angamuthu, Wen-Jung Chang, Duen-Ren Hou. "Anti-addition of Dimethylsulfoxonium Methylide to Acyclic α, β-Unsaturated Ketones and Its Application in Formal Synthesis of an Eicosanoid." ACS Omega, 2017, 2(8), 4088-4099.
  1. Min-Ching Chung , Yung-Hsiang Chan , Wen-Jung Chang and Duen-Ren Hou. "Synthesis of 2, 3-dihydro-1 H-pyrroles by intramolecular cyclization of N-(3-butynyl)-sulfonamides." Organic & biomolecular chemistry, 2017, 15(17), 3783-3790.
  1. Le Thi Ngoc Chuc, Cheng-Sheng Chen, Wei-Shang Lo, Po-Chuan Shen, Yi-Chen Hsuan, Hui-Hsu Gavin Tsai, Fa-Kuen Shieh, Duen-Ren Hou."Long-Range Olefin Isomerization Catalyzed by Palladium (0) Nanoparticles." ACS Omega, 2017, 2(2), 698-711.
  1. Wohn-Jenn Leu, Sharada Prasanna Swain, She-Hung Chan, Jui-Ling Hsu, Shih-Ping Liu, Mei-Ling Chan, Chia-Chun Yu, Lih-Ching Hsu, Yen-Lin Chou, Wei-Ling Chang, Duen-Ren Hou, Jih-Hwa Guh. "Non-immunosuppressive triazole-based small molecule induces anticancer activity against human hormone-refractory prostate cancers: the role in inhibition of PI3K/AKT/mTOR and c-Myc signaling pathways." Oncotarget, 2016, 7(47), 76995.
  1. ChengYu Chung, Venkatachalam Angamuthu, LongShiang Li, DuenRen Hou. "PalladiumCatalyzed Allylic Substitution for the Synthesis of Pericosines." Asian Journal of Organic Chemistry, 2016, 5(11), 1327-1333.
  1. Ya-Jen Chang, Yi-Chen Hsuan, Alan Chuan-Ying Lai, Yun-Chiann Han, Duen-Ren Hou. "Synthesis of α-C-Galactosylceramide via Diastereoselective Aziridination: The New Immunostimulant 4′-epi-C-Glycoside of KRN7000." Organic letters, 2016, 18(4), 808-811.
  1. Ching-Nung Chen , Duen-Ren Hou. "Enantioselective synthesis of (+)-brevipolide H." Organic & biomolecular chemistry, 2016, 14(28), 6762-6768.
  1. Sharada Prasanna Swain, YenLin Chou, DuenRen Hou. "Thioesterifications Free of Activating Agent and Thiol: A ThreeComponent Reaction of Carboxylic Acids, Thioureas, and Michael Acceptors." Advanced Synthesis & Catalysis, 2015, 357(12), 2644-2650.
年度 論文名稱
2014 Lin, J.-W.; Kurniawan, Y. D.; Chang, W.-J.; Leu, W.-J.; Chan, S.-H.; Hou, D.-R. “Asymmetric Synthesis of (−)-Brevipolide H through Cyclopropanation of the α,β-Unsaturated Ketone” Org. Lett, 16, 5328-5331. , 2014
2013 Diastereoselective vinylalumination for the synthesis of pericosine A, B and C, RSC Advances, vol. 4, pp. 91-97, 2013
2013 Total Synthesis of Quebrachamine through Macrolactamization, European Journal of Organic Chemistry, vol. 15, pp. 3109-3115, 2013
2013 Valproic acid enhances Oct4 promoter activity through PI3K​/Akt​/mTOR pathway activated nuclear receptors, Molecular and Cellular Endocrinology, vol. 383, pp. 147-158, 2013
2012 Phosphonium salts and aldehydes from the convenient, anhydrous reaction of aryl acetals and triphenylphosphine hydrobromide, ARKIVOC, vol. 3, pp. 98-108, 2012
2012 Synthesis of the decalin core of codinaeopsin via an intramolecular Diels-​Alder reaction, Organic & Biomolecular Chemistry, vol. 11, pp. 3846-3854, 2012
2012 Total synthesis of 14,​21-​diepi-​squamocin-​K, Tetrahedron, vol. 69, pp. 2971-2976, 2012
2012 Bortezomib congeners induce apoptosis of hepatocellular carcinoma via CIP2A inhibition, Molecules, vol. 18, pp. 15398-15411, 2012
2012 Formation of tetrahydrofurans via a 5-​endo-​tet cyclization of aziridines - synthesis of (-​)​-​pachastrissamine, Organic & Biomolecular Chemistry, vol. 11, pp. 5292-5299, 2012
2011 Ring-​closing metathesis and palladium-​catalyzed formate reduction to 3-​methyleneoxepanes. Formal synthesis of (-​)​-​zoapatanol, Tetrahedron, vol. 68, pp. 747-753, 2011
2011 Characterization of the role of protein-​cysteine residues in the binding with sodium arsenite, Archives of Toxicology, vol. 86, pp. 911-922, 2011
2011 Asymmetric synthesis of (+)​-​aspicilin, Journal of the Chinese Chemical Society, vol. 59, pp. 389-393, 2011
2010 Bortezomib Sensitizes HCC Cells to CS-​1008, an Antihuman Death Receptor 5 Antibody, through the Inhibition of CIP2A, Molecular Cancer Therapeutics, vol. 10, pp. 892-901, 2010
2009 Electronic effects of ruthenium-​catalyzed [3+2]​-​cycloaddition of alkynes and azides, Tetrahedron, vol. 66, pp. 9415-9420, 2009
2009 Cleavage of benzyl ethers by triphenylphosphine hydrobromide, Tetrahedron Letters, vol. 51, pp. 6143-6145, 2009
2009 Asymmetric synthesis of bis-​tetrahydrofuran cores in annonaceous acetogenins, Organic & Biomolecular Chemistry, vol. 8, pp. 3624-3626, 2009
2009 Asymmetric Synthesis of (-​)​-​Lentiginosine by Double Aza-​Michael Reaction, Abstracts of Papers, 241st ACS National Meeting & Exposition, vol. 25, pp. 4771-4773, 2009
2008 Reduction of 1-​pyrrolyl and 1-​indolyl carbamates to hemiaminals, Tetrahedron Letters, vol. 50, pp. 7169-7171, 2008
2008 1,​2,​3-​Triazole derivatives as new cannabinoid CB1 receptor antagonists, Bioorganic & medicinal chemistry letters, vol. 19, pp. 1022-1025, 2008
2007 Asymmetric synthesis of 4- and 5-​substituted pipecolic esters by ring-​closing metathesis and palladium-​catalyzed formate reduction, Journal of Organic Chemistry, vol. 73, pp. 6877-6880, 2007
2006 Formation of 4,​5,​6,​7-​Tetrahydroisoindoles by Palladium-​Catalyzed Hydride Reduction, Journal of Organic Chemistry, vol. 72, pp. 9231-9239, 2006