謝發坤
職稱 教授兼副國際長
姓名 謝發坤
電子郵件 fshieh@ncu.edu.tw
聯絡電話 (03) 4227151 ext. 65948
網站 http://shiehfklab.wix.com/home
專業領域 生物化學
研究專長 酵素催化,綠色合成金屬有機骨架材料,酵素有機骨架複合材料應用
學歷
國家 學校名稱 系所 學位
臺灣 交通大學 應用化學系 學士
臺灣 交通大學 生物科技所 碩士
美國 加州大學聖塔芭芭拉分校(UC Santa Barbara) 化學所 博士
經歷
服務機關名稱 單位 職務 期間
北海道大學(Hokkaido University) 環工學院 訪問學者 2019.07 ~ 2019.09
中央大學 理學院 副院長 2018.08 ~ 2020.07
中央大學 化學系 教授 2018.08 ~ 迄今
北海道大學(Hokkaido University) 工學院 訪問學者 2017.07 ~ 2017.10
中央大學 化學系 副教授 2014.08 ~ 2018.07
中央大學 化學系 助理教授 2008.01 ~ 2014.07
美國加州大學洛杉磯分校(UC Los Angeles) 化學系 博士後研究 2007.08 ~ 2008.07
美國加州大學聖塔芭芭拉分校(UC Santa Barbara) 化學系 博士後研究 2007.02 ~ 2007.07
美國阿拉巴馬州大學伯明罕分校(UA Birmingham) 化學系 鑑識科學博士班訓練 2001.01 ~ 2002.01
榮譽
類別 年度 獎項名稱 頒獎單位
校外榮譽 2021 全球前 2% 頂尖科學家
校內榮譽 2021 中央大學優秀傑出論文獎(2014~2021)
校內榮譽 2021 中央大學傑出研究 (2018~2021)
校內榮譽 2013 中央大學服務學習傑出導師
校內榮譽 2011 中央大學理學院教學優良教師
校外榮譽 1999 教育部公費留學獎學金2001-2004
實驗室

生物化學實驗室網站Welcome to visit !
 
International Visiting Student Program: 派駐學生於美國麻州波士頓學院 (Boston College) 日本北海道大學(Hokkaido University),分別與當地共同合作的宗老師實驗室(The Tsung Research Group)神谷老師實驗室(The Kamiya Research Group)進行訪問學者計畫

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研究方向: 新一代奈米孔洞粒子,酵素催化,藥物傳輸


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1.利用具微孔性(Microporous)的類沸石咪唑骨架材料(Zeolite Imidazolate Frameworks, ZIFs),開發生物分子包覆載體及藥物傳遞系統。

 
期刊論文

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  1. Pei-Hsiang Hsu, Chien-Chun Chang, Tsu-Hao Wang, Phuc Khanh Lam, Ming-Yu Wei, Ching-Tien Chen, Chin-Yu Chen, Lien-Yang Chou*, and Fa-Kuen Shieh*."Rapid Fabrication of Biocomposites by Encapsulating Enzymes into Zn-MOF-74 via a Mild Water-Based Approach."ACS Appl. Mater. Interfaces 2021, 13, 44, 52014–52022                                                           

  2.  Sergejus Balčiūnas, Diana Pavlovaitė, Martynas Kinka, Jyun-Yi Yeh, Po-Chun Han, Fa-Kuen Shieh, Kevin C.-W. Wu ,Mantas Šimėnas, Robertas Grigalaitis and Jūras Banys*, "Dielectric Spectroscopy of Water Dynamics in Functionalized UiO-66 Metal-Organic Frameworks." Molecules, 2020, 25(8), 1962.                                                                                             

  3. Sheng-Yu Chen, Wei-Shang Lo, Yi-Da Huang, Xiaomeng Si, Fu-Siang Liao, Shang-Wei Lin, Benjamin P. Williams, Ting-Qian Sun, Hao-Wei Lin, Yuanyuan An, Tu Sun, Yanhang Ma, Hsiao-Ching Yang*, Lien-Yang Chou*, Fa-Kuen Shieh*, Chia-Kuang Tsung*. "Probing Interactions between Metal–Organic Frameworks and Freestanding Enzymes in a Hollow Structure." Nano Letters, 2020, 20(9), 6630-6635.                                                                                                                                              

  4. Hannelore Konnerth,Babasaheb M.Matsagar, Season S.Chen, Martin H.G.Prechtlc, Fa-Kuen Shieh*, Kevin C.-W.Wu* "Metal-organic framework (MOF)-derived catalysts for fine chemical production." Coordination Chemistry Reviews, 2020, 416, 213319.                                                                                                                                                           

  5. Jih Ru Hwu, Wen-Chieh Huang, Shu-Yu Lin, Kui-Thong Tan, Yu-Chen Hu, Fa-Kuen Shieh, Sergey O. Bachurin, Alexey Ustyugov, Shwu-Chen Tsay. "Chikungunya virus inhibition by synthetic coumarin–guanosine conjugates." European journal of medicinal chemistry, 2019, 166, 136-143.                                                                                                                                 

  6. Chiu, Chih-Chiang, Fa-Kuen Shieh, and Hui-Hsu Gavin Tsai*. "Ligand Exchange in the Synthesis of Metal–Organic Frameworks Occurs Through Acid-Catalyzed Associative Substitution." Inorganic chemistry, 2019, 58(21), 14457-14466.      
     

  7. Saikat Dutta, Jeonghun Kim, Pin‐Hsun Hsieh, Yu‐Shen Hsu, Yusuf  Valentino Kaneti, Fa-Kuen Shieh*, Yusuke Yamauchi*, Kevin C.‐W. Wu*. "Nanoarchitectonics of Biofunctionalized Metal–Organic Frameworks with Biological Macromolecules and Living Cells." Small Methods, 2019, 3(11).1900213.                                                                                                                     

  8. Tz-Han Wei, Shi-Hong Wu, Yi-Da Huang, Wei-Shang Lo, Benjamin P. Williams, Sheng-Yu Chen, Hsun-Chih Yang, Yu-Shen Hsu, Zih-Yin Lin, Xin-Hua Chen, Pei-En Kuo, Lien-Yang Chou*, Chia-Kuang Tsung* & Fa-Kuen Shieh*. "Rapid mechanochemical encapsulation of biocatalysts into robust metal–organic frameworks." Nature communications, 2019, 10(1), 1-8.         
                                                                                                    

  9. Sergejus Balčiu̅nas, Mantas Šimėnas*, Diana Pavlovaitė, Martynas Kinka, Fa-Kuen Shieh, Kevin C.-W Wu, Ju̅ras Banys, Robertas Grigalaitis. "Low-Frequency Dipolar Dynamics and Atmospheric Effects in ZIF-90 Metal–Organic Framework." The Journal of Physical Chemistry C, 2018, 123(1), 631-636.                                                                                                            

  10. Yusuf Valentino Kaneti, Saikat Dutta, Md. S. A. Hossain, Muhammad J. A. Shiddiky, Kuo‐Lun Tung, Fa‐Kuen Shieh, Chia‐Kuang Tsung, Kevin C.‐W. Wu*, Yusuke Yamauchi*. "Strategies for improving the functionality of zeolitic imidazolate frameworks: Tailoring nanoarchitectures for functional applications." Advanced Materials, 2017, 29(38), 1700213.                   
     

  11. Jih Ru Hwu*, D. Balaji Chandrasekhar, Kuo Chu Hwang, Chun‐Cheng Lin, Jia‐Cherng Horng, Fa‐Kuen Shieh. "Reductive Deamination by Benzyne for Deoxy Sugar Synthesis through a Domino Reaction." ChemistryOpen, 2017, 6(3), 331-335.       
     

  12. Yi-Hao Huang, Wei-Shang Lo, Yun-Wei Kuo, Wen-Jin Chen, Chia-Her Lin, Fa-Kuen Shieh*. "Green and rapid synthesis of zirconium metal–organic frameworks via mechanochemistry: UiO-66 analog nanocrystals obtained in one hundred seconds." Chemical Communications, 2017, 53(43), 5818-5821.               
                                                                                  

  13. Fu-Siang Liao, Wei-Shang Lo, Yu-Shen Hsu, Chang-Cheng Wu, Shao-Chun Wang, Fa-Kuen Shieh*, Joseph V. Morabito, Lien-Yang Chou, Kevin C.-W. Wu, Chia-Kuang Tsung*. "Shielding against unfolding by embedding enzymes in metal–organic frameworks via a de novo approach." Journal of the American Chemical Society, 2017, 139(19), 6530-6533.              
     

  14. Le Thi Ngoc Chuc, Cheng-Sheng Chen, Wei-Shang Lo, Po-Chuan Shen, Yi-Chen Hsuan, Hui-Hsu Gavin Tsai, Fa-Kuen Shieh*, Duen-Ren Hou*. "Long-Range Olefin Isomerization Catalyzed by Palladium (0) Nanoparticles." ACS Omega, 2017, 2(2), 698-711.                                                                                                                                      

  15. Chia‐I Yen, Szu‐Mam Liu, Wei‐Shang Lo, Jhe‐Wei Wu, Yi‐Hsin Liu, Rong‐Jie Chein, Renqiang Yang,. Kevin C.‐W. Wu, Jih Ru Hwu, Nianhan Ma*, Fa‐Kuen Shieh*. "Cytotoxicity of Postmodified Zeolitic Imidazolate Framework‐90 (ZIF‐90) Nanocrystals: Correlation between Functionality and Toxicity." Chemistry–A European Journal, 2016, 22(9), 2925-2929.   
         

  16. Shwu-Chen Tsay*, Shu-Yu Lin, Wen-Chieh Huang, Ming-Hua Hsu, Kuo Chu Hwang, Chun-Cheng Lin, Jia-Cherng Horng, I-Chia Chen, Jih Ru Hwu*, Fa-Kuen Shieh, Pieter Leyssen, Johan Neyts*. "Synthesis and Structure-activity relationships of imidazole-coumarin conjugates against hepatitis C virus." Molecules, 2016, 21(2), 228.                     
                                           

  17. Shanlin Qiao, Ting Wang, Wei Huang, Jia-Xing Jiang, Zhengkun Du, Fa-Kuen Shieh*, Renqiang Yang*. "Dendrimer-like conjugated microporous polymers." Polymer Chemistry, 2016, 7(6), 1281-1289.         
                                                                  

  18. Shao-Chun Wang, Yu-Shen Hsu, Chia-Teng Hsiao, Chang-Cheng Wu, Yu-Chein Sue, Saad M. Alshehri, Tansir Ahamad, Yusuke Yamauchi, Jeffrey E. Chen, Kevin C.-W. Wu, Fa-Kuen Shieh. "Annulated Mesoporous Silica as Potent Lanthanide Ion Adsorbents and Magnetic Resonance Contrast Enhancing Agents." Journal of Inorganic and Organometallic Polymers and Materials, 2016, 26(1), 165-171.                                                                                                                                           

  19. Victor Malgras, Qingmin Ji, Yuichiro Kamachi, Taizo Mori, Fa-Kuen Shieh, Kevin C.-W. Wu, Katsuhiko Ariga*, Yusuke Yamauchi*. "Templated synthesis for nanoarchitectured porous materials." Bulletin of the Chemical Society of Japan, 2015, 88(9), 1171-1200.                    
     

  20. Jih Ru Hwu*, Mohit Kapoor, Shwu-Chen Tsay*, Chun-Cheng Lin, Kuo Chu Hwang, Jia-Cherng Horng, I-Chia Chen, Fa-Kuen Shieh, Pieter Leyssen, Johan Neyts*. "Benzouracil–coumarin–arene conjugates as inhibiting agents for chikungunya virus." Antiviral research, 2015, 118, 103-109.
     

  21. Fa-Kuen Shieh*, Shao-Chun Wang, Chia-I Yen, Chang-Cheng Wu, Saikat Dutta, Lien-Yang Chou, Joseph V. Morabito, Pan Hu, Ming-Hua Hsu, Kevin C.-W. Wu*, Chia-Kuang Tsung*. "Imparting functionality to biocatalysts via embedding enzymes into nanoporous materials by a de novo approach: size-selective sheltering of catalase in metal–organic framework microcrystals." Journal of the American Chemical Society, 2015, 137(13), 4276-4279.                         
                                         

  22. Yu-Te Liao, Saikat Dutta, Ching-Hsuan Chien, Chien-Chieh Hu, Fa-Kuen Shieh, Chia-Her Lin, Kevin C.-W. Wu. "Synthesis of mixed-ligand zeolitic imidazolate framework (ZIF-8-90) for CO2 adsorption." Journal of Inorganic and Organometallic Polymers and Materials, 2015, 25(2), 251-258.                                                                                                                            

  23. Lien-Yang Chou, Pan Hu, Jia Zhuang, Joseph V. Morabito, Ka Chon Ng, Ya-Chuan Kao, Shao-Chun Wang, Fa-Kuen Shieh, Chun-Hong Kuo*, Chia-Kuang Tsung*. "Formation of hollow and mesoporous structures in single-crystalline microcrystals of metal–organic frameworks via double-solvent mediated overgrowth." Nanoscale, 2015, 7(46), 19408-19412.                          
     

  24. Malay Pramanik, Fa-Kuen Shieh, Saad M. Alshehri, Zeid Abdullah Alothman, Kevin C.-W. Wu*, Yusuke Yamauchi*. "Template-free synthesis of nanoporous gadolinium phosphonate as a magnetic resonance imaging (MRI) agent." RSC Advances, 2015, 5(53), 42762-42767.                                                                                                                                         

  25. Shanlin Qiao, Wei Huang, Zhengkun Du, Xianghui Chen, Fa-Kuen Shieh, Renqiang Yang*. "Phosphine oxide-based conjugated microporous polymers with excellent CO2 capture properties." New Journal of Chemistry, 2015, 39(1), 136-141.