侯敦仁
職稱 教授兼貴重儀器中心主任
姓名 侯敦仁
電子郵件
Phone： (03) 4227151 ext. 65981
專業領域 有機化學
研究興趣 開發具有生物活性之天然物，近年來加入研究利用亞硝鎓鹽進行苯環上的取代基轉換。
學歷
國家 學校名稱 系所 學位
臺灣 臺灣大學 化學系 學士
臺灣 臺灣大學 化學系 碩士
美國 德州大學 化學系 博士
經歷
服務機關名稱 單位 職務 期間
國立中央大學 貴重儀器中心 主任 2025.02 ~ 迄今
國立中央大學 化學學系 主任 2015.08 ~ 2018.07
國立中央大學 化學系 教授 2011.01 ~ 迄今
國立中央大學 化學系 副教授 2006.01 ~ 2011.01
國立中央大學 化學系 助理教授 2003.01 ~ 2006.01
國立高雄大學 應化系 助理教授 2001.01 ~ 2003.01
美國德州大學 博士後研究 2000.01 ~ 2001.01
美國德州農工大學 博士後研究 1998.01 ~ 2000.01
榮譽
類別 年度 獎項名稱 頒獎單位
校內榮譽 2011 中央大學學術研究傑出獎
個人研究
研究興趣:
我們開發出新型的有機反應並應用在有機合成的領域，包住我們合成目標天然物及具特殊性質的有機分子。
近年也與其他研究單位合作，嘗試做出適合用於正子照影的藥物。
同時我們也開發新型的方法，利用亞硝鎓鹽以改變苯環及各種氧化反應。

目前研究的主題有︰
1. 利用掌性源(chiral pool)進行不對稱合成(asymmetric synthesis)。
2. 利用亞硝鎓鹽(nitrosonium salt)進行苯環的鹵化(halogenation)。
3. 利用亞硝鎓鹽(nitrosonium salt)進行各式氧化反應
期刊論文
  1. Pin-Hsien Chen, Shu-Jung Hsu, Cheng-Chun Chen, Jui-Chen Fu, Duen-Ren Hou*. "Synthesis of Diarylamines via Nitrosonium-Initiated C-N Bond Formatio." Journal of Organic Chemistry, 2024, 89(14), 10316-10326.
  2. Pin-Hsien Chen, Shu-Jung Hsu, Duen-Ren Hou*. "Nitrosonium Ion Catalyzed Oxidative Bromination of Arenes" Advanced Synthesis & Catalysis, 2024, 366(7), 1575-1582.
  3. Chun-Wei Yeh, Chia-Chi Feng, Pei-Lin Chen, Yi-Jhen Jhou, and Duen-Ren Hou*. "Enantioselective Synthesis of Nabscessin C." The Journal of Organic Chemistry, 88(19), 2023, 13528-13534.
  4. Hung-Che Chen, Chi-Yun Liu, Venkatachalam Angamuthu, Wei-Chen Chen, Chi-Sheng Wen, Duen-Ren Hou*. "Synthesis of Optically Active Organofluorides by Ring Opening of Oxazolidinone-Fused Aziridines. " Org. Lett. 2023, 25(1), 190-194.
  5. Cheng-Chun Chen, Tzu-Hsuan Kuan, Wen-Wei Yuan, Shih-En Chen, Jui-Chen Fu, Yang-Xun Chen, Hui-Hsu Gavin Tsai,* and Duen-Ren Hou,*“Brønsted Acid-Promoted Benzannulation of o-Alkynylbenzaldehyde and Alkyne, and the Positive Effect of Propargyl Alcohol”2022, Advanced Synthesis & Catalysis, Volume: 364, Pages: 4122-4134.
  6. Thi Anh Hong Nguyen and Duen-Ren Hou*“Direct Acetoxylation of Arenes”2021, Organic Letters, Volume: 23, Issue: 21, Pages: 8127-8131.
  7. Tzu-Hsuan Kuan and Duen-Ren Hou*“Synthesis of 2‑Aryl Acetophenones via Hydrobromination and Oxyisomerization of (o‑Arylethynyl)benzyl Alcohols”2021, Journal of Organic Chemistry, Volume: 86, Issue: 9, Pages: 6907-6917.
  8. Chi-Yun Liu, Venkatachalam Angamuthu, Wei-Chen Chen, and Duen-Ren Hou*“Synthesis of Methyl L‑Kijanosides by Regio- and Stereoselective Ring Opening of 2‑Oxazolidinone-Fused Aziridines”2020, Organic Letters, Volume: 22, Issue: 6, Pages: 2246-2250.
  9. Hsin-Ying Wu, Wei-Yi Wang, Chia-Chi Feng, and Duen-Ren Hou*“Asymmetric Synthesis of Nabscessin A from Inositol and D‑Camphor”2020, Journal of Organic Chemistry, Volume: 85, Issue: 20, Pages: 13153-13159.
  10. Chi-Yun Liu, Venkatachalam Angamuthu, Wei-Chen Chen, and Duen-Ren Hou. "Synthesis of Methyl l-Kijanosides by Regio-and Stereoselective Ring Opening of 2-Oxazolidinone-Fused Aziridines. " Organic Letters, 2020, 22(6), 2246-2250.
  11. She-Hung Chan, Wohn-Jenn Leu, Sharada Prasanna Swain, Jui-Ling Hsu, Duen-Ren Hou, and Jih-Hwa Guh."Mechanistic Study of Triazole Based Aminodiol Derivatives in Leukemic Cells—Crosstalk between Mitochondrial Stress-Involved Apoptosis and Autophagy."International Journal of Molecular Sciences, 2020, 21(7), 2470.
  12. Le Thi Ngoc Chuc, Thi Anh Hong Nguyen and Duen-Ren Hou. "Acid–base-sensitive allylic oxidation of 2-allylbenzoic acids to form phthalides. "Organic & Biomolecular Chemistry, 2020 18(14), 2758-2768.
  13. Hsin-Ying Wu, Wei-Yi Wang, Chia-Chi FengChia-Chi Feng, Chia-Chi Feng, Duen-Ren Hou, "Asymmetric Synthesis of Nabscessin A from Inositol and d-Camphor. " The Journal of Organic Chemistry, 2020, 85(20), 13153-13159.
  14. Yi-Hua Sheng, Wohn-Jenn Leu, Ching-Nung Chen, Jui-Ling Hsu, Ying-Tung Liu, Lih-Ching Hsu, Duen-Ren Hou,Jih-Hwa Guh, "The (+)-Brevipolide H Displays Anticancer Activity against Human Castration-Resistant Prostate Cancer: The Role of Oxidative Stress and Akt/mTOR/p70S6K-Dependent Pathways in G1 Checkpoint Arrest and Apoptosis." Molecules, 2020, 25(12), 2929.
  15. Ya-Ching Chang, Yu-Ling Tseng, Wohn-Jenn Leu, Chi-Min Du, Yi-Huei Jiang, Lih-Ching Hsu, Jui-Ling Hsu, Duen-Ren Hou, Jih-Hwa Guh, "Discovery of novel agents on spindle assembly checkpoint to sensitize vinorelbine-induced mitotic cell death against human non-small cell lung cancers." International journal of molecular sciences, 2020, 21(16), 5608.
  16. Yu‐Chun Wu, Yi Jhong, Hui‐Jie Lin, Sharada Prasanna Swain, Hui‐Hsu Gavin Tsai, Duen‐Ren Hou, "Organocatalyzed Enantioselective Michael Addition of 2‐Hydroxypyridines and α,β‐Unsaturated 1,4‐Dicarbonyl Compounds." Advanced Synthesis & Catalysis, 2019, 361(21), 4966-4982.
  17. Trimurtulu, Kotipalli and Duen-Ren Hou "Synthesis of 3-Bromoindenes from 4-Alkynyl Alcohols/Sulfonamides and Aldehydes via Prins Cyclization, Ring-Opening and Friedel-Crafts Reactions." Asian Journal of Organic Chemistry, 2019, 8(8), 1561-1571.
  18. Kotipalli, Trimurtulu, and Duen-Ren Hou "Synthesis of Indenes by a BF3· OEt2-Mediated, One-Pot Reaction of Aryl Homopropargyl Alcohols, Aldehydes, and Arenes." Organic letters, 2018, 20(16), 4787-4790.
  19. Agata Szymaszkiewicz, Marta Zielinska, Kun Li, Mani Ramanathan, Safiul Alam,  Duen-Ren Hou, Jakub Fichna, Martin Storr "Novel derivatives of 1, 2, 3-triazole,cannabinoid-1 receptor ligands modulate gastrointestinal motility in mice." Naunyn-Schmiedeberg's archives of pharmacology, 2018, 391(4), 435-444.
  20. Venkatachalam Angamuthu, Wen-Jung Chang, Duen-Ren Hou. "Anti-addition of Dimethylsulfoxonium Methylide to Acyclic α, β-Unsaturated Ketones and Its Application in Formal Synthesis of an Eicosanoid." ACS Omega, 2017, 2(8), 4088-4099.
  21. Min-Ching Chung , Yung-Hsiang Chan , Wen-Jung Chang and Duen-Ren Hou. "Synthesis of 2, 3-dihydro-1 H-pyrroles by intramolecular cyclization of N-(3-butynyl)-sulfonamides." Organic & biomolecular chemistry, 2017, 15(17), 3783-3790.
  22. Le Thi Ngoc Chuc, Cheng-Sheng Chen, Wei-Shang Lo, Po-Chuan Shen, Yi-Chen Hsuan, Hui-Hsu Gavin Tsai, Fa-Kuen Shieh,
    Duen-Ren Hou."Long-Range Olefin Isomerization Catalyzed by Palladium (0) Nanoparticles." ACS Omega, 2017, 2(2), 698-711.
  23. Wohn-Jenn Leu, Sharada Prasanna Swain, She-Hung Chan, Jui-Ling Hsu, Shih-Ping Liu, Mei-Ling Chan, Chia-Chun Yu, Lih-Ching Hsu, Yen-Lin Chou, Wei-Ling Chang, Duen-Ren Hou, Jih-Hwa Guh. "Non-immunosuppressive triazole-based small molecule induces anticancer activity against human hormone-refractory prostate cancers: the role in inhibition of PI3K/AKT/mTOR and c-Myc signaling pathways." Oncotarget, 2016, 7(47), 76995.
  24. Cheng‐Yu Chung, Venkatachalam Angamuthu, Long‐Shiang Li, Duen‐Ren Hou. "Palladium‐Catalyzed Allylic Substitution for the Synthesis of Pericosines." Asian Journal of Organic Chemistry, 2016, 5(11), 1327-1333.
  25. Ya-Jen Chang, Yi-Chen Hsuan, Alan Chuan-Ying Lai, Yun-Chiann Han, Duen-Ren Hou. "Synthesis of α-C-Galactosylceramide via Diastereoselective Aziridination: The New Immunostimulant 4′-epi-C-Glycoside of KRN7000." Organic letters, 2016, 18(4), 808-811.
  26. Ching-Nung Chen , Duen-Ren Hou. "Enantioselective synthesis of (+)-brevipolide H." Organic & biomolecular chemistry, 2016, 14(28), 6762-6768.
  27. Sharada Prasanna Swain, Yen‐Lin Chou, Duen‐Ren Hou. "Thioesterifications Free of Activating Agent and Thiol: A Three‐Component Reaction of Carboxylic Acids, Thioureas, and Michael Acceptors." Advanced Synthesis & Catalysis, 2015, 357(12), 2644-2650.