中央化學

研究興趣

本研究室的研究核心主題為金屬錯合物的合成及結構解析，並對其物理(光、電、磁)及化學性質(反應性、催化活性)深入研究開發。

這些錯合物可應用於各式催化反應或是化學偵測探針上。並可將結構拓展至一維、二維及三維金屬錯合物材料以應用在各式尖端產業應用上。

配位化合物合成、結構鑑定及性質研究

金屬錯合物合成與有機合成有許多相似的地方，但也有許多獨特的地方，最主要的差異來自於金屬-配位基鍵結的多樣性，及其獨特的鍵結生成的可逆性及可置換性。金屬錯化合物的主體結構可以分成配位基的部分及金屬的部分，配位基主要是以有機化學方法修飾以產生各式結構，之後依據不同金屬核心利用不同反應手段使其結合產生配位化合物。

 

催化劑開發及反應機構研究

許多配位不飽和的特別金屬錯合物具有相當高的化學活性，因此常應用在催化反應中做為催化劑。一般金屬催化劑可以藉由調整其結構以達到改變錯合物的反性特性與催化性質，另外，由於金屬催化反應常會以不同於有機反應的反應機構進行催化反應，因此對於金屬催化劑的反應機構做出深入研究除了能幫助我們了解其反應發生的原因，更重要的是能幫助我們調整整體反應系統，以達到更高的反應性能。

特殊反應及試劑開發

金屬錯合物(或有機金屬試劑)除了可以用於催化反應中做為催化劑外，它們也可以做為反應中的主要關鍵試劑，例如格林納試劑為非常重要的碳陰離子提供試劑，可用於各式加成反應中，但由於市售的金屬錯合物試劑在其結構上有一定的限制性，開發具有特殊結構或反應性的試劑也可幫助我們擴展反應，並研究出新的化學合成方法。

錯合物材料

金屬錯合物由於具有良好的結構修飾性及特殊的物理及化學性質，因此可以將其由單分子結構利用各式化學方法將其結合，以生成一維分子線、二維奈米片狀材料、或是三維網絡材料。如此，可以將其特別的物理及化學特性疊加，以產生具有特殊性質的材料，並可應用在如能源儲存，顯示器，電催化劑等各式應用中。

1. Ganta, P. K.; Huang, F.; Ben Halima, T.; Kamaraj, R.; Chu, Y.-T.; Tseng, H.-C.; Ding, S.; Wu, K.-H.*; Chen, H.-Y.* Evolution of Aluminum Aminophenolate Complexes in the Ring-Opening Polymerization of ε-Caprolactone: Electronic and Amino-Chelating Effects. Dalton Trans. 2025, 54, 511–520.
2. Wu, L.-J.; Kottalanka, R. K.; Chu, Y.-T.; Lin, Z.-I.; Chang, C.-J.; Ding, S.; Chen, H.-Y.*; Wu, K.-H.*; Chen, C.-K.* A Comparative Study of Titanium Complexes Bearing 2-(Arylideneamino)phenolates and 2-((Arylimino)methyl)phenolates as Catalysts for Ring-Opening Polymerization of ε-Caprolactone and L-Lactide. Dalton Trans. 2024, 53, 15660–15670.
3. Su, R.-R.; Ganta, P. K.; Cheng, C.-A.; Hu, Y.-T.; Chang, Y.-C.; Chang, C.-J.; Ding, S.; Chen, H.-Y.*; Wu, K.-H.* Ring-Opening Polymerization of ε-Caprolactone and L-Lactide Using Ethyl Salicylate-Bearing Zinc Complexes as Catalysts. Mol. Catal. 2023, 537, 112965.
4. Kosuru, S. R.; Lai, F.-J.; Chang, Y.-L.; Li, C.-Y.; Lai, Y.-C.; Ding, S.; Wu, K.-H.*; Chen, H.-Y.*; Lo, Y.-H. Collaboration between Trinuclear Aluminum Complexes Bearing Bipyrazoles in the Ring-Opening Polymerization of ε-Caprolactone. Inorg. Chem. 2021, 60, 10535–10544.
5. Wu, K.-H.; Cao, J.; Pal, T.; Yang, H.; Nishihara, H.* Electrochemically Synthesized Bis(diimino)metal Coordination Nanosheets as Ultrastable Electrocatalysts for Hydrogen Evolution Reaction. ACS Appl. Energy Mater. 2021, 4, 5403–5412.
6. Wu, K.-H.*; Sakamoto, R.; Maeda, H.; Phua, E. J. H.; Nishihara, H.* Ultralong π-Conjugated Bis(terpyridine)metal Polymer Wires Covalently Bound to a Carbon Electrode: Fast Redox Conduction and Redox Diode Characteristics. Molecules 2021, 26, 4267.
7. Lai, F.-J.; Huang, T.-W.; Chang, Y.-L.; Chang, H.-Y.; Lu, W.-Y.; Ding, S.; Chen, H.-Y.*; Chiu, C.-C.*; Wu, K.-H.* Titanium Complexes Bearing 2,6-Bis(o-hydroxyalkyl)pyridine Ligands in the Ring-Opening Polymerization of L-Lactide and ε-Caprolactone. Polymer 2020, 204, 122860.
8. Lai, F.-J.; Chung, S.-J.; Chang, Y.-L.; Huang, Y.-T.; Chang, C.-J.; Ding, S.; Chen, H.-Y.*; Wu, K.-H.*; Lin, Y.-F.* Comparison of L-Lactide Polymerization Using Magnesium Complexes Bearing 2-(Arylideneamino)phenolate and 2-((Arylimino)methyl)phenolate Ligands. Eur. Polym. J. 2020, 135, 109864.
9. Lai, F.-J.; Huang, T.-W.; Chang, Y.-L.; Chang, H.-Y.; Lu, W.-Y.; Ding, S.; Chen, H.-Y.*; Chiu, C.-C.*; Wu, K.-H.* Titanium Complexes Bearing 2,6-Bis(o-hydroxyalkyl)pyridine Ligands in the Ring-Opening Polymerization of L-Lactide and ε-Caprolactone. Polymer 2020, 204, 122860.
10. Chen, G.-J.; Zeng, S.-X.; Lee, C.-H.; Chang, Y.-L.; Chang, C.-J.; Ding, S.; Chen, H.-Y.*; Wu, K.-H.*; Chang, I.-J.* Synthesis of Zinc Complexes Bearing Pyridine Derivatives and Their Application in the Polymerization of ε-Caprolactone and L-Lactide. Polymer 2020, 194, 122374.
11. Improvement in zinc complexes bearing Schiff base in ring-opening polymerization of ε-caprolactone: A five-membered ring system" Feng-Jie Lai, Li-Ling Chiuc, Chieh-Ling Lee, Wei-Yi Lu, Yi-Chun Lai, Shangwu Ding, Hsuan-Ying Chen,* Kuo-Hui Wu* Polymer, 2019, 182, 121812-121821.
12. Synthesis and Characterization of N,N,O-Tridentate Aminophenolate Zinc Complexes and Their Catalysis in the Ring-Opening Polymerization of Lactides" Wei-Yi Lu, Kuo-Hui Wu,* Hsuan-Ying Chen,* and Chu-Chieh Lin* Front. Chem. 2019, 7, 189.
13. Novel aluminum complexes bearing 2-(aminomethylene)malonate ligands with high efficiency and controllability in ring-opening polymerization of ε-Caprolactone" Chi-Chi Changa, Yung-Chi Chang, Wei-Yi Lu, Yi-Chun Lai, Kuo-Hui Wu, Ya-Fan Lin,* Hsuan-Ying Chen* Eur. Polym. J. 2019, 115, 399–408.
14. Optimization of six-membered ring aluminum complexes in ε-caprolactone polymerization" Wei-Yi Lua, Yung-Chi Chang, Cheng-Jie Lian, Kuo-Hui Wu, Michael Y. Chiang, Hsuan-Ying Chen,* Chu-Chieh Lina,⁎ Bao-Tsan Ko* Eur. Polym. J. 2019, 114, 151–163.
15. Oxidation-Promoted Interfacial Synthesis of Redox-Active Bis(diimino)nickel Nanosheet" Eunice J H Phua, Kuo-Hui Wu, Keisuke Wada, Tetsuro Kusamoto, Hiroaki Maeda, Jian Cao, Ryota Sakamoto, Hiroyasu Masunaga, Sono Sasaki, Jia-Wei Mei, Wei Jiang, Feng Liu, Hiroshi Nishihara Chem. Lett. 2018, 47, 126-129.
16. Bis(aminothiolato)nickel nanosheet as a redox switch for conductivity and an electrocatalyst for the hydrogen evolution reaction" Xinsen Sun, Kuo-Hui Wu, Ryota Sakamoto, Tetsuro Kusamoto, Hiroaki Maeda, Xiaojuan Ni, Wei Jiang, Wei, Feng Liu, Sono Sasaki, Hiroyasu Masunaga, Hiroshi Nishihara* Chem. Sci. 2017, 8, 8078-8085.
17. Conducting π-Conjugated Bis(iminothiolato)nickel Nanosheet" Xinsen Sun, Kuo-Hui Wu, Ryota Sakamoto, Tetsuro Kusamoto, Hiroaki Maeda, Hiroshi Nishihara* Chem. Lett. 2017, 46, 1072-1075.
18. Electrochemical fabrication of one-dimensional porphyrinic wires on electrodes" Suzaliza Mustafar, Kuo-Hui Wu, Ryojun Toyoda, Kenji Takada, Hiroaki Maeda, Mariko Miyachi, Ryota Sakamoto,* Hiroshi Nishihara* Inorg. Chem. Front. 2016, 3, 370.
19. Heteroleptic bis(dipyrrinato)copper(II) and nickel(II) complexes" Ryojun Toyoda, Mizuho Tsuchiya, Ryota Sakamoto,* Ryota Matsuoka, Kuo-Hui Wu, Yohei Hattori, Hiroshi Nishihara* Dalton Trans. 2015, 44, 15103.
20. π-Conjugated bis(terpyridine)metal complex molecular wires" Ryota Sakamoto, Wu Kuo-Hui, Ryota Matsuoka, Hiroaki Maeda, Hiroshi Nishihara* Chem. Soc. Rev. 2015, 44, 7698-7714.
21. A bis(terpyridine)iron network polymer on carbon for a potential energy storage material" Kuo-Hui Wu, Hiroaki Maeda, Tetsuya Kambe, Ken Hoshiko, Eunice Jia Han Phua, Ryota Sakamoto, Hiroshi Nishihara* Dalton Trans. 2013, 42, 15877.
22. Enantioselective additions of aryltitanium tris(isopropoxide) to ketones: structure of [(i-PrO)2Ti{μ-(S)-BINOLate} (μ-O-i-Pr)TiPh(O-i-Pr)2], study of mechanistic and stereochemical insights" Kuo-Hui Wu, Yi-Yin Kuo, Chien-An Chen, Yi-Ling Huang, Han-Mou Gau* Adv. Synth. Catal., 2013, 355, 1001.
23. Instantaneous room-temperature and highly enantioselective ArTi(O-i-Pr)3 additions to aldehydes" Kuo-Hui Wu, Shuangliu Zhou, Chien-An Chen, Mao-Chi Yang, Ruei-Tang Chiang, Chi Ren Chen, Han-Mou Gau* Chem. Commun., 2011, 47, 11668.
24. Highly enantioselective arylation of aldehydes and ketones using AlArEt2(THF) as aryl sources" Shuangliu Zhou, Kuo-Hui Wu, Chien-An Chen, Han-Mou Gau* J. Org. Chem., 2009, 74, 3500–3505
25. Chiral tertiary 2-furyl alcohols: diversified key intermediates to bioactive compounds. their enantioselective synthesis via (2-furyl)aluminum addition to ketones catalyzed by a titanium catalyst of (S)-binol." Kuo-Hui Wu, Da-Wei Chuang, Chien-An Chen, Han-Mou Gau* Chem. Commun., 2008, 2343-2345.
26. A new aspect of magnesium bromide-promoted enantioselective aryl additions of triaryl(tetrahydrofuran)aluminum to ketones catalyzed by a titanium(IV) catalyst of trans-1,2-bis(hydroxycamphorsulfonylamino) cyclohexane" Chien-An Chen, Kuo-Hui Wu, Han-Mou Gau* Adv. Synth. Catal., 2008, 350, 1626-1634.
27. Synthesis and application of polymer-supported N-sulfonylated aminoalcohols as enantioselective catalysts" Chien-An Chen, Kuo-Hui Wu, Han-Mou Gau* Polymer, 2008, 49, 1512-1519.
28. Highly enantioselective aryl additions of [AlAr3(thf)] to ketones catalyzed by a titanium(IV) catalyst of (S)-binol." Chien-An Chen, Kuo-Hui Wu, Han-Mou Gau* Angew. Chem. Int. Ed., 2007, 119, 5469-5472.
29. Vinyldiazolactone as a vinylcarbene precursor: highly selective C−H insertion and cyclopropanation reactions" Darren Bykowski, Kou-Hui Wu, Michael P. Doyle* J. Am. Chem. Soc., 2006, 128, 16038–16039.
30. Polystyrene-supported N-sulfonylated amino alcohols and their applications to titanium(IV) complexes catalyzed enantioselective diethylzinc additions to aldehydes" Xin-Ping Hui, Chien-An Chen, Kuo-Hui Wu, Han-Mou Gau* Chirality, 2006, 19, 10-15.
31. Remarkably efficient enantioselective titanium(IV)−(R)-H8-BINOLate catalyst for arylations to aldehydes by triaryl(tetrahydrofuran)aluminum reagents" Kuo-Hui Wu, Han-Mou Gau* J. Am. Chem. Soc., 2006, 128, 14808–14809.
32. Mechanism of asymmetric dialkylzinc addition to aldehydes catalyzed by titanium(IV) complexes of N-sulfonylated β-amino alcohols" Kuo-Hui Wu, Han-Mou Gau* Organometallics, 2004, 24, 580-588.
33. Structural and electronic effects in asymmetric diethylzinc addition to benzaldehyde catalyzed by titanium(IV) complexes of N-sulfonylated β-amino alcohols" Kuo-Hui Wu, Han-Mou Gau* Organometallics, 2003, 23, 5193-5200.