Shieh, Fa-Kuen
Professor
Name Shieh, Fa-Kuen
Email
Phone： (03) 4227151 ext. 65948
Website http://shiehfklab.wix.com/home
Professional field：
Biochemistry
Research Interest Enzyme Kinetics, Bio-Conjugation, Drug Delivery ,Porous materials
Diploma
Experience
Organization Title Department Job Title Duration
2021.02 ~ 2025.01
2019.07 ~ 2019.09
2018.08 ~ 2020.07
2018.08 ~ Up to today
2017.07 ~ 2017.10
National Central University （NCU） Chemistry Associate Professor 2014.08 ~ 2018.07
National Central University (NCU) Chemistry Assistant Professor 2008.01 ~ 2014.07
University of California at Los Angeles (UCLA) Chemistry Postdoctoral Research Associate 2007.08 ~ 2008.07
University of California at Santa Barbara (UCSB) Chemistry Postdoctoral Research Associate 2007.02 ~ 2007.07
University of Alabama at Birmingham (UAB) Chemistry Doctoral Training in Forensic Science 2001.09 ~ 2002.06
Personal Honor
Honor Category Year Award Name Awarding Unit
Inside School Honor 2023
Inside School Honor 2023
Outside School Honor 2022
Inside School Honor 2022 2022中央大學傑出教師 中央大學
Outside School Honor 2021
Inside School Honor 2021 Outstanding paper Award in College of Science in NCU
Inside School Honor 2021 Outstanding paper Award in College of Science in NCU
Inside School Honor 2013 Outstanding paper Award in College of Science in NCU
Inside School Honor 2011 Outstanding Teaching Award in College of Science in NCU
Outside School Honor 1999 Government Funded Student Award, Ministry of Education in Taiwan.
Personal Lab
Personal Journal
● T. Hieu Vo, S.-W. Lin, M.-C. Lin, P.-Y. Kuan, J.-H. Chen, H.-K. Huang, W.-T. Liu, H. Xu, A. Li, Y.-A. Hsu, L. Wan, P. K. Lam,* L.-Y. Chou,* H.-C. Yang,* and F.-K. Shieh*."Exploring Enzyme Encapsulation Efficiency in MOFs Using Ecofriendly Approaches" ChemSusChem (2024) (Q1, IF: 7.5; Ranking 40/230 (17.4%):)
● S.-W. Lin, P. K. Lam, C.-T. Wu, K.-H. Su, C.-F. Sung, S.-R. Huang, J.-W. Chang, O. Shih, Y.-Q. Yeh, T. H. Vo, H.-K. Tsao, H.-T. Hsieh, U-S. Jeng,* F.-K. Shieh,* and H.-C. Yang*. "Decoding the Biomimetic Mineralization of Metal–Organic Frameworks in Water" ACS Nano (2024) 18, 36, 25170–25182 (Q1, IF: 15.8; Ranking: 14/230 (6.0%) ▲: 2)
● T. H. Vo, P. K. Lam, R.-m. Chuang, F.-K. Shieh*, Y.-J. Sheng* and H.-K. Tsao*“One-Step, Additive-free Fabrication of Highly Stretchable and Ultra-Tough Physical Polyvinyl Alcohol-Based Eutectogels for Strain Sensors” Chem. Eng. J. (2024) 493, 152877(Q1, IF: 15.1; Ranking: 6/160(3.75%) ▲: 1)
● L. Lapčinskis, A. Šutka*, M. Kinka*, F.-K. Shieh*, R. Grigalaitis et al.,” Controlling the magnitude and polarity of surface charges in PEBA polymers by   adding UIO-66 MOFs” Mater. Adv. (2024) 5, 4242 (IF:5.0; Ranking: 188/424; ▲: 1)
● P. K. Lam, T. H. Vo, J.-H. Chen, S.-W. Lin, H.-C. Yang* and F.-K. Shieh*et al., "Green and Ultrafast One-Pot Mechanochemical Approach for Efficient Biocatalyst Encapsulation in MOFs: Insights from Experiment and Computation
J. Mater. Chem. A (2023), 11, 24678 - 24685 (Q1, IF: 11.9; Ranking: 18/172 (10.4%); ▲: 3)
● P. K. Lam, L.-Y. Chou*, and F.-K. Shieh* et al., "Controlled Encapsulation of Gold Nanoparticles into Zr-Metal–Organic Frameworks with Improved Detection Limitation of Volatile Organic Compounds via Surface-Enhanced Raman Scattering" Inorg. Chem (2023), 62, 37, 14896–14901(Q1, IF: 4.6; Ranking 3/44(6.8%); ▲: 4)
● Sutka,* F.-K. Shieh,* M. Kinka, C.-C. Chang et al., " Triboelectric behaviour of selected MOFs in contact with metals" RSC Adv. (2022) 13, 41-46 (Q1, IF: 3.9; Ranking: 91/230; ▲: 7)
● P.-H. Hsu, C.-C. Chang, T.-H. Wang, L.-Y. Chou*, and F.-K. Shieh*et al., "Rapid Fabrication of Biocomposites by Encapsulating Enzymes into Zn-MOF-74 via a Mild Water-Based Approach" ACS Appl. Mater. Interfaces (2021) 13, 44, 52014–52022 (Q1, IF: 9.5; Ranking: 52/424 (12.3%); ▲: 46)
● S.-Y. Chen, H.-C. Yang*, L.-Y. Chou*, F.-K. Shieh*, C.-K. Tsung* et al.,’ "Probing Interactions between Metal-Organic Frameworks and Freestanding Enzymes in a Hollow Structure" Nano Lett. (2020) 20, 9, 6630–6635 (Q1, IF: 10.8; Ranking 23/230 (10%); ▲: 84)
● H. Konnerth, F.-K. Shieh*, K. C.-W. Wu* et al., " Metal-organic framework (MOF)-derived catalysts for fine chemical production" Coord. Chem. Rev. (2020) 213319-Review (IF: 20.6; Ranking :2/44 (4.5%); ▲: 535-Top 1% paper)
● T.-H. Wei, L.-Y. Chou*, C.-K. Tsung* & F.-K. Shieh* et al., "Rapid mechanochemical encapsulation of biocatalysts into robust metal–organic frameworks" Nat. Commun. (2019) 5002 (Q1, IF: 16.6; Ranking: 7/137 (5.1%); ▲: 182; Top 50 Chemistry and Materials Sciences Articles)
● S. Dutta, F.‐K. Shieh*, Y. Yamauchi*, K. C.‐W. Wu*et al., "Nanoarchitectonics of Biofunctionalized Metal–Organic Frameworks with Biological Macromolecules and Living Cells" Small Methods (2019) 1900213 –Review (IF: 12.4; Ranking: 31/172 (18%); ▲: 80)
● F.-S. Liao, F.-K. Shieh,* and C.-K. Tsung* et al., "Shielding Against Unfolding by Embedding Enzymes in Metal-Organic Frameworks via a de novo Approach." J. Am. Chem. Soc. (2017), 139, 6530-6533 (Q1, IF: 15.0; Ranking: 10/230(4.3%); ▲: 318 -Top 1% paper)
● Y.-H. Huang and F.-K. Shieh* et al., "Green and Rapid Synthesis of Zirconium Metal-organic Frameworks via Mechanochemistry: UiO-66 Analog nanocrystals obtained in one hundred seconds." Chem. Commun. (2017), 53, 5818-5821 (Q1, IF: 4.9; Ranking 63/230; ▲: 114)

  1. Trung Hieu Vo, Phuc Khanh Lam, Ruei-min Chuang, Fa-Kuen Shieh*, Yu-Jane Sheng*, Heng-Kwong Tsao*. "One-step, additive-free fabrication of highly stretchable and ultra-tough physical polyvinyl alcohol-based eutectogels for strain sensors". Chemical Engineering Journal, 2024, 493, 152877.
  2. Linards Lapčinskis, Andris Šutka*, Martynas Kinka*, Fa-Kuen Shieh*, Līva Ģērmane*, Sergejus Balčiūnas, Artis Linartsa and Robertas Grigalaitisb. "Controlling the magnitude and polarity of surface charges in PEBA polymers by adding UIO-66 MOFs". Materials Advances, 2024, 5, 4242-4250.
  3. Phuc Khanh Lam, Trung Hieu Vo, Jing-Hui Chen, Shang-Wei Lin, Chiao-Ling Kuo, Jian-Jie Liao, Kuan-Yu Chen, Sen-Ruo Huang, Dong Li, Yun-Hsiang Chang, Hsuan-Yi Chen, Haw-Ting Hsieh, YuAn Hsu, Heng-Kwong Tsao, Hsiao-Ching Yang* and Fa-Kuen Shieh*. “Green and Ultrafast One-Pot Mechanochemical Approach for Efficient Biocatalyst Encapsulation in MOFs: Insights from Experiment and Computation”. Journal of Materials Chemistry A, 2023, 11,24678-24685 . 
  4. Phuc Khanh Lam, Jian-Jie Liao, Miao-Chun Lin, Yu-Hsiu Li, Tsu-Hao Wang, Hsin-Kai Huang, Yu-An Hsu, Hao-Ying Patterson Hsieh, Pu-Yun Kuan, Ching-Tien Chen, Guo-Xiu Hao, Chia-Kuang Tsung, Kevin C.-W. Wu, Andris Šutka, Martynas Kinka, Lien-Yang Chou*, and Fa-Kuen Shieh*. ”Controlled Encapsulation of Gold Nanoparticles into Zr-Metal–Organic Frameworks with Improved Detection Limitation of Volatile Organic Compounds via Surface-Enhanced Raman Scattering”. Inorganic Chemistry, 2023, 62, 37, 14896–14901.
  5. Andris Šutka*, Fa-Kuen Shieh*, Martynas Kinka, Linards Lapčinskis, Chien-Chun Chang, Phuc Khanh Lam, Kaspars Pudzs and Osvalds Vernersa “Triboelectric behaviour of selected MOFs in contact with metals”. RSC Advances, 2021, 13, 41-46.
  6. Hailong Li, Anqi Kang, Bolin An, Lien-yang Chou, Fa-kuen Shieh, Chia-kuang Tsung, Chao Zhong. “Encapsulation of bacterial cells in cytoprotective ZIF-90 crystals as living composites”. Materials Today Bio, 2021, 10, 100097.
  7. Yang Li, Wei-Shang Lo, Furui Zhang, Xiaomeng Si, Lien-Yang Chou, Xiao-Yuan Liu, Benjamin P. Williams, Yu-Hsiu Li, Seung-Hea Jung, Yu-Shen Hsu, Fu-Siang Liao, Fa-Kuen Shieh, Mariam N. Ismail, Wenyu Huang, and Chia-Kuang Tsung. “Creating an Aligned Interface between Nanoparticles and MOFs by Concurrent Replacement of Capping Agents”. Journal of the American Chemical Society, 2021, 143 (13), 5182-5190.
  8. Pei-Hsiang Hsu, Chien-Chun Chang, Tsu-Hao Wang, Phuc Khanh Lam, Ming-Yu Wei, Ching-Tien Chen, Chin-Yu Chen, Lien-Yang Chou*, and Fa-Kuen Shieh*."Rapid Fabrication of Biocomposites by Encapsulating Enzymes into Zn-MOF-74 via a Mild Water-Based Approach."ACS Appl. Mater. Interfaces, 2021, 13, 44, 52014–52022                 
  9. Sergejus Balčiūnas, Diana Pavlovaitė, Martynas Kinka, Jyun-Yi Yeh, Po-Chun Han, Fa-Kuen Shieh, Kevin C.-W. Wu ,Mantas Šimėnas, Robertas Grigalaitis and Jūras Banys*. "Dielectric Spectroscopy of Water Dynamics in Functionalized UiO-66 Metal-Organic Frameworks." Molecules, 2020, 25(8), 1962. 
  10. Sheng-Yu Chen, Wei-Shang Lo, Yi-Da Huang, Xiaomeng Si, Fu-Siang Liao, Shang-Wei Lin, Benjamin P. Williams, Ting-Qian Sun, Hao-Wei Lin, Yuanyuan An, Tu Sun, Yanhang Ma, Hsiao-Ching Yang*, Lien-Yang Chou*, Fa-Kuen Shieh*, Chia-Kuang Tsung*. "Probing Interactions between Metal–Organic Frameworks and Freestanding Enzymes in a Hollow Structure." Nano Letters, 2020, 20(9), 6630-6635. 
  11. Hannelore Konnerth,Babasaheb M.Matsagar, Season S.Chen, Martin H.G.Prechtlc, Fa-Kuen Shieh*, Kevin C.-W.Wu* "Metal-organic framework (MOF)-derived catalysts for fine chemical production." Coordination Chemistry Reviews, 2020, 416, 213319. 
  12. Jih Ru Hwu, Wen-Chieh Huang, Shu-Yu Lin, Kui-Thong Tan, Yu-Chen Hu, Fa-Kuen Shieh, Sergey O. Bachurin, Alexey Ustyugov, Shwu-Chen Tsay. "Chikungunya virus inhibition by synthetic coumarin–guanosine conjugates." European journal of medicinal chemistry, 2019, 166, 136-143.                                                        
  13. Chiu, Chih-Chiang, Fa-Kuen Shieh, and Hui-Hsu Gavin Tsai*. "Ligand Exchange in the Synthesis of Metal–Organic Frameworks Occurs Through Acid-Catalyzed Associative Substitution." Inorganic chemistry, 2019, 58(21), 14457-14466.      
  14. Saikat Dutta, Jeonghun Kim, Pin‐Hsun Hsieh, Yu‐Shen Hsu, Yusuf  Valentino Kaneti, Fa-Kuen Shieh*, Yusuke Yamauchi*, Kevin C.‐W. Wu*. "Nanoarchitectonics of Biofunctionalized Metal–Organic Frameworks with Biological Macromolecules and Living Cells." Small Methods, 2019, 3(11).1900213.                                                                       
  15. Tz-Han Wei, Shi-Hong Wu, Yi-Da Huang, Wei-Shang Lo, Benjamin P. Williams, Sheng-Yu Chen, Hsun-Chih Yang, Yu-Shen Hsu, Zih-Yin Lin, Xin-Hua Chen, Pei-En Kuo, Lien-Yang Chou*, Chia-Kuang Tsung* & Fa-Kuen Shieh*. "Rapid mechanochemical encapsulation of biocatalysts into robust metal–organic frameworks." Nature communications, 2019, 10(1), 1-8.         
  16. Sergejus Balčiu̅nas, Mantas Šimėnas*, Diana Pavlovaitė, Martynas Kinka, Fa-Kuen Shieh, Kevin C.-W Wu, Ju̅ras Banys, Robertas Grigalaitis. "Low-Frequency Dipolar Dynamics and Atmospheric Effects in ZIF-90 Metal–Organic Framework." The Journal of Physical Chemistry C, 2018, 123(1), 631-636.
  17. Yusuf Valentino Kaneti, Saikat Dutta, Md. S. A. Hossain, Muhammad J. A. Shiddiky, Kuo‐Lun Tung, Fa‐Kuen Shieh, Chia‐Kuang Tsung, Kevin C.‐W. Wu*, Yusuke Yamauchi*. "Strategies for improving the functionality of zeolitic imidazolate frameworks: Tailoring nanoarchitectures for functional applications." Advanced Materials, 2017, 29(38), 1700213.              
  18. Jih Ru Hwu*, D. Balaji Chandrasekhar, Kuo Chu Hwang, Chun‐Cheng Lin, Jia‐Cherng Horng, Fa‐Kuen Shieh. "Reductive Deamination by Benzyne for Deoxy Sugar Synthesis through a Domino Reaction." ChemistryOpen, 2017, 6(3), 331-335.       
  19. Yi-Hao Huang, Wei-Shang Lo, Yun-Wei Kuo, Wen-Jin Chen, Chia-Her Lin, Fa-Kuen Shieh*. "Green and rapid synthesis of zirconium metal–organic frameworks via mechanochemistry: UiO-66 analog nanocrystals obtained in one hundred seconds." Chemical Communications, 2017, 53(43), 5818-5821.               
  20. Fu-Siang Liao, Wei-Shang Lo, Yu-Shen Hsu, Chang-Cheng Wu, Shao-Chun Wang, Fa-Kuen Shieh*, Joseph V. Morabito, Lien-Yang Chou, Kevin C.-W. Wu, Chia-Kuang Tsung*. "Shielding against unfolding by embedding enzymes in metal–organic frameworks via a de novo approach." Journal of the American Chemical Society, 2017, 139(19), 6530-6533.           
  21. Le Thi Ngoc Chuc, Cheng-Sheng Chen, Wei-Shang Lo, Po-Chuan Shen, Yi-Chen Hsuan, Hui-Hsu Gavin Tsai, Fa-Kuen Shieh*, Duen-Ren Hou*. "Long-Range Olefin Isomerization Catalyzed by Palladium (0) Nanoparticles." ACS Omega, 2017, 2(2), 698-711.
  22. Chia‐I Yen, Szu‐Mam Liu, Wei‐Shang Lo, Jhe‐Wei Wu, Yi‐Hsin Liu, Rong‐Jie Chein, Renqiang Yang,. Kevin C.‐W. Wu, Jih Ru Hwu, Nianhan Ma*, Fa‐Kuen Shieh*. "Cytotoxicity of Postmodified Zeolitic Imidazolate Framework‐90 (ZIF‐90) Nanocrystals: Correlation between Functionality and Toxicity." Chemistry–A European Journal, 2016, 22(9), 2925-2929.    
  23. Shwu-Chen Tsay*, Shu-Yu Lin, Wen-Chieh Huang, Ming-Hua Hsu, Kuo Chu Hwang, Chun-Cheng Lin, Jia-Cherng Horng, I-Chia Chen, Jih Ru Hwu*, Fa-Kuen Shieh, Pieter Leyssen, Johan Neyts*. "Synthesis and Structure-activity relationships of imidazole-coumarin conjugates against hepatitis C virus." Molecules, 2016, 21(2), 228.                                 
  24. Shanlin Qiao, Ting Wang, Wei Huang, Jia-Xing Jiang, Zhengkun Du, Fa-Kuen Shieh*, Renqiang Yang*. "Dendrimer-like conjugated microporous polymers." Polymer Chemistry, 2016, 7(6), 1281-1289.
  25. Shao-Chun Wang, Yu-Shen Hsu, Chia-Teng Hsiao, Chang-Cheng Wu, Yu-Chein Sue, Saad M. Alshehri, Tansir Ahamad, Yusuke Yamauchi, Jeffrey E. Chen, Kevin C.-W. Wu, Fa-Kuen Shieh. "Annulated Mesoporous Silica as Potent Lanthanide Ion Adsorbents and Magnetic Resonance Contrast Enhancing Agents." Journal of Inorganic and Organometallic Polymers and Materials, 2016, 26(1), 165-171. 
  26. Victor Malgras, Qingmin Ji, Yuichiro Kamachi, Taizo Mori, Fa-Kuen Shieh, Kevin C.-W. Wu, Katsuhiko Ariga*, Yusuke Yamauchi*. "Templated synthesis for nanoarchitectured porous materials." Bulletin of the Chemical Society of Japan, 2015, 88(9), 1171-1200.
  27. Jih Ru Hwu*, Mohit Kapoor, Shwu-Chen Tsay*, Chun-Cheng Lin, Kuo Chu Hwang, Jia-Cherng Horng, I-Chia Chen, Fa-Kuen Shieh, Pieter Leyssen, Johan Neyts*. "Benzouracil–coumarin–arene conjugates as inhibiting agents for chikungunya virus." Antiviral research, 2015, 118, 103-109.
  28. Fa-Kuen Shieh*, Shao-Chun Wang, Chia-I Yen, Chang-Cheng Wu, Saikat Dutta, Lien-Yang Chou, Joseph V. Morabito, Pan Hu, Ming-Hua Hsu, Kevin C.-W. Wu*, Chia-Kuang Tsung*. "Imparting functionality to biocatalysts via embedding enzymes into nanoporous materials by a de novo approach: size-selective sheltering of catalase in metal–organic framework microcrystals." Journal of the American Chemical Society, 2015, 137(13), 4276-4279.
  29. Yu-Te Liao, Saikat Dutta, Ching-Hsuan Chien, Chien-Chieh Hu, Fa-Kuen Shieh, Chia-Her Lin, Kevin C.-W. Wu. "Synthesis of mixed-ligand zeolitic imidazolate framework (ZIF-8-90) for CO2 adsorption." Journal of Inorganic and Organometallic Polymers and Materials, 2015, 25(2), 251-258.                                                                                                                  
  30. Lien-Yang Chou, Pan Hu, Jia Zhuang, Joseph V. Morabito, Ka Chon Ng, Ya-Chuan Kao, Shao-Chun Wang, Fa-Kuen Shieh, Chun-Hong Kuo*, Chia-Kuang Tsung*. "Formation of hollow and mesoporous structures in single-crystalline microcrystals of metal–organic frameworks via double-solvent mediated overgrowth." Nanoscale, 2015, 7(46), 19408-19412.      
  31. Malay Pramanik, Fa-Kuen Shieh, Saad M. Alshehri, Zeid Abdullah Alothman, Kevin C.-W. Wu*, Yusuke Yamauchi*. "Template-free synthesis of nanoporous gadolinium phosphonate as a magnetic resonance imaging (MRI) agent." RSC Advances, 2015, 5(53), 42762-42767.                                                                                                                                         
  32. Shanlin Qiao, Wei Huang, Zhengkun Du, Xianghui Chen, Fa-Kuen Shieh, Renqiang Yang*. "Phosphine oxide-based conjugated microporous polymers with excellent CO2 capture properties." New Journal of Chemistry, 2015, 39(1), 136-141.