
職稱 | 教授兼副國際長 |
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姓名 | 謝發坤 |
電子郵件 | |
Phone: | (03) 4227151 ext. 65948 |
網站 | http://shiehfklab.wix.com/home |
專業領域 | 生物化學 |
研究興趣 | 酵素催化,綠色合成金屬有機骨架材料,酵素有機骨架複合材料應用 |
國家 | 學校名稱 | 系所 | 學位 |
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美國 | 加州大學聖塔芭芭拉分校(UC Santa Barbara) | 化學所 | 博士 |
臺灣 | 交通大學 | 生物科技所 | 碩士 |
臺灣 | 交通大學 | 應用化學系 | 學士 |
服務機關名稱 | 單位 | 職務 | 期間 |
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中央大學 | 國際事務處 | 副國際長 | 2021.02 ~ 迄今 |
北海道大學(Hokkaido University) | 環工學院 | 訪問學者 | 2019.07 ~ 2019.09 |
中央大學 | 理學院 | 副院長 | 2018.08 ~ 2020.07 |
中央大學 | 化學系 | 教授 | 2018.08 ~ 迄今 |
北海道大學(Hokkaido University) | 工學院 | 訪問學者 | 2017.07 ~ 2017.10 |
中央大學 | 化學系 | 副教授 | 2014.08 ~ 2018.07 |
中央大學 | 化學系 | 助理教授 | 2008.01 ~ 2014.07 |
美國加州大學洛杉磯分校(UC Los Angeles) | 化學系 | 博士後研究 | 2007.08 ~ 2008.07 |
美國加州大學聖塔芭芭拉分校(UC Santa Barbara) | 化學系 | 博士後研究 | 2007.02 ~ 2007.07 |
美國阿拉巴馬州大學伯明罕分校(UA Birmingham) | 化學系 | 鑑識科學博士班訓練 | 2001.01 ~ 2002.01 |
類別 | 年度 | 獎項名稱 | 頒獎單位 |
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校內榮譽 | 2023 | 中大拔尖論文貢獻獎 | |
校內榮譽 | 2023 | 中央大學優良產學合作獎 | |
校外榮譽 | 2022 | 延平高中傑出校友 | |
校內榮譽 | 2022 | 2022中央大學傑出教師 | 中央大學 |
校外榮譽 | 2021 | 全球前 2% 頂尖科學家 | |
校內榮譽 | 2021 | 中央大學優秀傑出論文獎(2014~2023) | |
校內榮譽 | 2021 | 中央大學傑出研究 (2018~2023) | |
校內榮譽 | 2013 | 中央大學服務學習傑出導師 | |
校內榮譽 | 2011 | 中央大學理學院教學優良教師 | |
校外榮譽 | 1999 | 教育部公費留學獎學金2001-2004 |
生物化學實驗室網站- Welcome to visit !
International Visiting Student Program: 派駐學生於美國麻州波士頓學院 (Boston College) 和日本北海道大學(Hokkaido University),分別與當地共同合作的宗老師實驗室(The Tsung Research Group)和神谷老師實驗室(The Kamiya Research Group)進行訪問學者計畫


研究方向: 新一代奈米孔洞粒子,酵素催化,藥物傳輸


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Phuc Khanh Lam, Trung Hieu Vo, Jing-Hui Chen, Shang-Wei Lin, Chiao-Ling Kuo, Jian-Jie Liao, Kuan-Yu Chen, Sen-Ruo Huang, Dong Li, Yun-Hsiang Chang, Hsuan-Yi Chen, Haw-Ting Hsieh, YuAn Hsu, Heng-Kwong Tsao, Hsiao-Ching Yang* and Fa-Kuen Shieh*. “Green and Ultrafast One-Pot Mechanochemical Approach for Efficient Biocatalyst Encapsulation in MOFs: Insights from Experiment and Computation”. Journal of Materials Chemistry A, 2023,
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Phuc Khanh Lam, Jian-Jie Liao, Miao-Chun Lin, Yu-Hsiu Li, Tsu-Hao Wang, Hsin-Kai Huang, Yu-An Hsu, Hao-Ying Patterson Hsieh, Pu-Yun Kuan, Ching-Tien Chen, Guo-Xiu Hao, Chia-Kuang Tsung, Kevin C.-W. Wu, Andris Šutka, Martynas Kinka, Lien-Yang Chou*, and Fa-Kuen Shieh*. ” Controlled Encapsulation of Gold Nanoparticles into Zr-Metal–Organic Frameworks with Improved Detection Limitation of Volatile Organic Compounds via Surface-Enhanced Raman Scattering”. Inorganic Chemistry, 2023, 62, 37, 14896–14901.
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Andris Šutka*, Fa-Kuen Shieh*, Martynas Kinka, Linards Lapčinskis, Chien-Chun Chang, Phuc Khanh Lam, Kaspars Pudzs and Osvalds Vernersa “Triboelectric behaviour of selected MOFs in contact with metals”. RSC Advances, 2021, 13, 41-46.
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Hailong Li, Anqi Kang, Bolin An, Lien-yang Chou, Fa-kuen Shieh, Chia-kuang Tsung, Chao Zhong. “Encapsulation of bacterial cells in cytoprotective ZIF-90 crystals as living composites”. Materials Today Bio, 2021, 10, 100097.
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Yang Li, Wei-Shang Lo, Furui Zhang, Xiaomeng Si, Lien-Yang Chou, Xiao-Yuan Liu, Benjamin P. Williams, Yu-Hsiu Li, Seung-Hea Jung, Yu-Shen Hsu, Fu-Siang Liao, Fa-Kuen Shieh, Mariam N. Ismail, Wenyu Huang, and Chia-Kuang Tsung. “Creating an Aligned Interface between Nanoparticles and MOFs by Concurrent Replacement of Capping Agents”. Journal of the American Chemical Society, 2021, 143 (13), 5182-5190.
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Pei-Hsiang Hsu, Chien-Chun Chang, Tsu-Hao Wang, Phuc Khanh Lam, Ming-Yu Wei, Ching-Tien Chen, Chin-Yu Chen, Lien-Yang Chou*, and Fa-Kuen Shieh*."Rapid Fabrication of Biocomposites by Encapsulating Enzymes into Zn-MOF-74 via a Mild Water-Based Approach."ACS Appl. Mater. Interfaces, 2021, 13, 44, 52014–52022
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Sergejus Balčiūnas, Diana Pavlovaitė, Martynas Kinka, Jyun-Yi Yeh, Po-Chun Han, Fa-Kuen Shieh, Kevin C.-W. Wu ,Mantas Šimėnas, Robertas Grigalaitis and Jūras Banys*. "Dielectric Spectroscopy of Water Dynamics in Functionalized UiO-66 Metal-Organic Frameworks." Molecules, 2020, 25(8), 1962.
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Sheng-Yu Chen, Wei-Shang Lo, Yi-Da Huang, Xiaomeng Si, Fu-Siang Liao, Shang-Wei Lin, Benjamin P. Williams, Ting-Qian Sun, Hao-Wei Lin, Yuanyuan An, Tu Sun, Yanhang Ma, Hsiao-Ching Yang*, Lien-Yang Chou*, Fa-Kuen Shieh*, Chia-Kuang Tsung*. "Probing Interactions between Metal–Organic Frameworks and Freestanding Enzymes in a Hollow Structure." Nano Letters, 2020, 20(9), 6630-6635.
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Hannelore Konnerth,Babasaheb M.Matsagar, Season S.Chen, Martin H.G.Prechtlc, Fa-Kuen Shieh*, Kevin C.-W.Wu* "Metal-organic framework (MOF)-derived catalysts for fine chemical production." Coordination Chemistry Reviews, 2020, 416, 213319.
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Jih Ru Hwu, Wen-Chieh Huang, Shu-Yu Lin, Kui-Thong Tan, Yu-Chen Hu, Fa-Kuen Shieh, Sergey O. Bachurin, Alexey Ustyugov, Shwu-Chen Tsay. "Chikungunya virus inhibition by synthetic coumarin–guanosine conjugates." European journal of medicinal chemistry, 2019, 166, 136-143.
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Chiu, Chih-Chiang, Fa-Kuen Shieh, and Hui-Hsu Gavin Tsai*. "Ligand Exchange in the Synthesis of Metal–Organic Frameworks Occurs Through Acid-Catalyzed Associative Substitution." Inorganic chemistry, 2019, 58(21), 14457-14466.
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Saikat Dutta, Jeonghun Kim, Pin‐Hsun Hsieh, Yu‐Shen Hsu, Yusuf Valentino Kaneti, Fa-Kuen Shieh*, Yusuke Yamauchi*, Kevin C.‐W. Wu*. "Nanoarchitectonics of Biofunctionalized Metal–Organic Frameworks with Biological Macromolecules and Living Cells." Small Methods, 2019, 3(11).1900213.
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Tz-Han Wei, Shi-Hong Wu, Yi-Da Huang, Wei-Shang Lo, Benjamin P. Williams, Sheng-Yu Chen, Hsun-Chih Yang, Yu-Shen Hsu, Zih-Yin Lin, Xin-Hua Chen, Pei-En Kuo, Lien-Yang Chou*, Chia-Kuang Tsung* & Fa-Kuen Shieh*. "Rapid mechanochemical encapsulation of biocatalysts into robust metal–organic frameworks." Nature communications, 2019, 10(1), 1-8.
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Sergejus Balčiu̅nas, Mantas Šimėnas*, Diana Pavlovaitė, Martynas Kinka, Fa-Kuen Shieh, Kevin C.-W Wu, Ju̅ras Banys, Robertas Grigalaitis. "Low-Frequency Dipolar Dynamics and Atmospheric Effects in ZIF-90 Metal–Organic Framework." The Journal of Physical Chemistry C, 2018, 123(1), 631-636.
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Yusuf Valentino Kaneti, Saikat Dutta, Md. S. A. Hossain, Muhammad J. A. Shiddiky, Kuo‐Lun Tung, Fa‐Kuen Shieh, Chia‐Kuang Tsung, Kevin C.‐W. Wu*, Yusuke Yamauchi*. "Strategies for improving the functionality of zeolitic imidazolate frameworks: Tailoring nanoarchitectures for functional applications." Advanced Materials, 2017, 29(38), 1700213.
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Jih Ru Hwu*, D. Balaji Chandrasekhar, Kuo Chu Hwang, Chun‐Cheng Lin, Jia‐Cherng Horng, Fa‐Kuen Shieh. "Reductive Deamination by Benzyne for Deoxy Sugar Synthesis through a Domino Reaction." ChemistryOpen, 2017, 6(3), 331-335.
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Yi-Hao Huang, Wei-Shang Lo, Yun-Wei Kuo, Wen-Jin Chen, Chia-Her Lin, Fa-Kuen Shieh*. "Green and rapid synthesis of zirconium metal–organic frameworks via mechanochemistry: UiO-66 analog nanocrystals obtained in one hundred seconds." Chemical Communications, 2017, 53(43), 5818-5821.
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Fu-Siang Liao, Wei-Shang Lo, Yu-Shen Hsu, Chang-Cheng Wu, Shao-Chun Wang, Fa-Kuen Shieh*, Joseph V. Morabito, Lien-Yang Chou, Kevin C.-W. Wu, Chia-Kuang Tsung*. "Shielding against unfolding by embedding enzymes in metal–organic frameworks via a de novo approach." Journal of the American Chemical Society, 2017, 139(19), 6530-6533.
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Le Thi Ngoc Chuc, Cheng-Sheng Chen, Wei-Shang Lo, Po-Chuan Shen, Yi-Chen Hsuan, Hui-Hsu Gavin Tsai, Fa-Kuen Shieh*, Duen-Ren Hou*. "Long-Range Olefin Isomerization Catalyzed by Palladium (0) Nanoparticles." ACS Omega, 2017, 2(2), 698-711.
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Chia‐I Yen, Szu‐Mam Liu, Wei‐Shang Lo, Jhe‐Wei Wu, Yi‐Hsin Liu, Rong‐Jie Chein, Renqiang Yang,. Kevin C.‐W. Wu, Jih Ru Hwu, Nianhan Ma*, Fa‐Kuen Shieh*. "Cytotoxicity of Postmodified Zeolitic Imidazolate Framework‐90 (ZIF‐90) Nanocrystals: Correlation between Functionality and Toxicity." Chemistry–A European Journal, 2016, 22(9), 2925-2929.
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Shwu-Chen Tsay*, Shu-Yu Lin, Wen-Chieh Huang, Ming-Hua Hsu, Kuo Chu Hwang, Chun-Cheng Lin, Jia-Cherng Horng, I-Chia Chen, Jih Ru Hwu*, Fa-Kuen Shieh, Pieter Leyssen, Johan Neyts*. "Synthesis and Structure-activity relationships of imidazole-coumarin conjugates against hepatitis C virus." Molecules, 2016, 21(2), 228.
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Shanlin Qiao, Ting Wang, Wei Huang, Jia-Xing Jiang, Zhengkun Du, Fa-Kuen Shieh*, Renqiang Yang*. "Dendrimer-like conjugated microporous polymers." Polymer Chemistry, 2016, 7(6), 1281-1289.
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Shao-Chun Wang, Yu-Shen Hsu, Chia-Teng Hsiao, Chang-Cheng Wu, Yu-Chein Sue, Saad M. Alshehri, Tansir Ahamad, Yusuke Yamauchi, Jeffrey E. Chen, Kevin C.-W. Wu, Fa-Kuen Shieh. "Annulated Mesoporous Silica as Potent Lanthanide Ion Adsorbents and Magnetic Resonance Contrast Enhancing Agents." Journal of Inorganic and Organometallic Polymers and Materials, 2016, 26(1), 165-171.
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Victor Malgras, Qingmin Ji, Yuichiro Kamachi, Taizo Mori, Fa-Kuen Shieh, Kevin C.-W. Wu, Katsuhiko Ariga*, Yusuke Yamauchi*. "Templated synthesis for nanoarchitectured porous materials." Bulletin of the Chemical Society of Japan, 2015, 88(9), 1171-1200.
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Jih Ru Hwu*, Mohit Kapoor, Shwu-Chen Tsay*, Chun-Cheng Lin, Kuo Chu Hwang, Jia-Cherng Horng, I-Chia Chen, Fa-Kuen Shieh, Pieter Leyssen, Johan Neyts*. "Benzouracil–coumarin–arene conjugates as inhibiting agents for chikungunya virus." Antiviral research, 2015, 118, 103-109.
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Fa-Kuen Shieh*, Shao-Chun Wang, Chia-I Yen, Chang-Cheng Wu, Saikat Dutta, Lien-Yang Chou, Joseph V. Morabito, Pan Hu, Ming-Hua Hsu, Kevin C.-W. Wu*, Chia-Kuang Tsung*. "Imparting functionality to biocatalysts via embedding enzymes into nanoporous materials by a de novo approach: size-selective sheltering of catalase in metal–organic framework microcrystals." Journal of the American Chemical Society, 2015, 137(13), 4276-4279.
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Yu-Te Liao, Saikat Dutta, Ching-Hsuan Chien, Chien-Chieh Hu, Fa-Kuen Shieh, Chia-Her Lin, Kevin C.-W. Wu. "Synthesis of mixed-ligand zeolitic imidazolate framework (ZIF-8-90) for CO2 adsorption." Journal of Inorganic and Organometallic Polymers and Materials, 2015, 25(2), 251-258.
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Lien-Yang Chou, Pan Hu, Jia Zhuang, Joseph V. Morabito, Ka Chon Ng, Ya-Chuan Kao, Shao-Chun Wang, Fa-Kuen Shieh, Chun-Hong Kuo*, Chia-Kuang Tsung*. "Formation of hollow and mesoporous structures in single-crystalline microcrystals of metal–organic frameworks via double-solvent mediated overgrowth." Nanoscale, 2015, 7(46), 19408-19412.
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Malay Pramanik, Fa-Kuen Shieh, Saad M. Alshehri, Zeid Abdullah Alothman, Kevin C.-W. Wu*, Yusuke Yamauchi*. "Template-free synthesis of nanoporous gadolinium phosphonate as a magnetic resonance imaging (MRI) agent." RSC Advances, 2015, 5(53), 42762-42767.
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Shanlin Qiao, Wei Huang, Zhengkun Du, Xianghui Chen, Fa-Kuen Shieh, Renqiang Yang*. "Phosphine oxide-based conjugated microporous polymers with excellent CO2 capture properties." New Journal of Chemistry, 2015, 39(1), 136-141.